Why Dhaka Is a Primate City free essay sample

A primate city is the leading city in its country or region, disproportionately larger than any others in the urban hierarchy. [1] A primate city distribution has one very large city with many much smaller cities and towns, and no intermediate-sized urban centres, in contrast to the linear rank-size distribution. [2] The law of the primate city was first proposed by the geographer Mark Jefferson in 1939. [3] He defines a primate city as being at least twice as large as the next largest city and more than twice as significant. A primate city is number one in its country in most aspects, like politics, economy, media, culture and universities. Contents * 1 Significance * 2 Examples * 3 See also * 4 Notes| Significance Not all countries have primate cities, but in those that do, the rest of the country depends on it for cultural, economic, political, and major transportation needs. [citation needed] On the other hand the primate city depends on the rest of the country as paying consumers of the cultural, economic, political and other services produced in the area. We will write a custom essay sample on Why Dhaka Is a Primate City or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The presence of a primate city in a country may indicate an imbalance in development  Ã¢â‚¬â€œ usually a progressive core, and a lagging periphery, on which the city depends for labor and other resources. [5] However, the urban structure is not directly dependent on a countrys level of economic development. Primate cities are major cities that works as the financial, political, and population centre of a country and is not rivaled in any of these aspects by any other city in that country. Usually the population of primate cities are twice as much as the second largest city in that country. Some of the most known primate cities would be London, Paris, Athens, Mexico City, Cairo or Kuala Lumpur where these cities serve as the political and economic centres of their respective country. Countries such as The United States, China, Canada, Australia or Brazil have several regional centres.

French Sequence of Tenses - Concordance des Temps

French Sequence of Tenses - Concordance des Temps Note:  This is a fairly advanced French lesson. If you are not comfortable with all of the grammar concepts listed to the right, please click the links to study those prerequisites before attempting this lesson. Prerequisites:Verb tenses: Present, Passà ©Ã‚  composà ©, Imperfect, Pluperfect, Future, Literary tensesVerb moods: Subjunctive, Conditional, ImperativeConjunctions, Relative pronouns, Subordinate clauses, Si clauses, Indirect speech When speaking French (or any other language), it is important to use the correct sequence of tenses. In complex sentences, there is a relationship between the verb in the main clause and the verb in the subordinate clause. Using the correct sequence of tenses is just as important as conjugating the verbs correctly and using the appropriate mood. For example, in French you cant say  Je ne savais pas que tu es à ©tudiant- you have to say  Je ne savais pas que tu à ©tais à ©tudiant. Likewise, in English, you would say I didnt know you were a student rather than I didnt know that you are a student. Because the verb in the main clause is in the past, the verb in the subordinate clause must be in the past as well. In order to determine the correct sequence of tenses, you need to start by examining the temporal relationship between the verbs in the two clauses. The action of the verb in the main clause may occur  before,  during, or  after  the action of the subordinate verb. It is this temporal relationship that dictates the sequence of tenses. Although the French sequence of tenses is usually the same as the English sequence, there are some exceptions, so dont rely on your English knowledge to determine the correct sequence of tenses in French. The following table shows the possible relationships between the tenses in the main and subordinate clauses. The action column indicates whether the action of the main verb occurs before, during, or after the action of the subordinate verb. Note that you often have a choice of tenses for the subordinate verb, thus it is up to you to choose the tense that expresses the correct nuance. At the same time (pardon the pun), you also need to be sure to use the correct mood: indicative, subjunctive, or conditional. Main verb Action Subordinate verb Present before Future Jespre que tu finiras. Subjunctive Je veux que tu finisses. during Present Je sais que tu as raison. Subjunctive Je doute que tu aies raison. after Pass compos Je sais quil a trich. Pass simple Je sais quil tricha. Imperfect Je sais quil avait raison. Pluperfect Je sais quil avait mang avant notre dpart. Past subjunctive Je doute quil ait trich. Future perfect Je sais quil sera dj parti. Future before Future Je te donnerai un livre que tu aimeras beaucoup. Subjunctive Jirai lecole avant quil ne se rveille. during Present Il tudiera pendant que je travaille. Subjunctive Je lachterai bien que tu aies plus dargent. after Pass compos Jirai au muse que tu as visit. Pass simple Jirai au muse que tu visitas. Imperfect Je verrai le film que tu aimais. Pluperfect Jaffirmerai quil tait parti avant le cours. Past subjunctive Je serai content condition quils aient tudi. Future perfect Je vous dirai quand nous aurons dcid. Note that the sequence of tenses for subordinate clauses is identical for main clauses in the present and future. Main verb Action Subordinate verb Past before Conditional Jai promis quil serait prt midi. Past conditional Si javais su, je taurais aid. *Imperfect subjunctive Je doutais quil parlt si bien. Present subjunctive Je doutais quil parle si bien. during Pass compos Jtudiais quand il est arriv. Pass simple Jtudiais quand il arriva. Imperfect Je savais quil exaggrait. *Imperfect subjunctive Je voulais quil et raison. Present subjunctive Je voulais quil ait raison. after Pluperfect Je savais quil avait trich. *Pluperfect subjunctive Je doutais quil et trich. Past subjunctive Je doutais quil ait trich. Conditional before *Imperfect subjunctive Je voudrais que tu le fisses. Present subjunctive Je voudrais que tu le fasses. during *Imperfect subjunctive Je saurais quil mentt. Present subjunctive Je saurais quil mente. after *Pluperfect subjunctive Je saurais quil et menti Past subjunctive Je saurais quil ait menti. *These literary tenses are nearly always replaced by their non-literary equivalents. The literary tense is the official tense to be used in the construction, but in reality, the imperfect subjunctive and pluperfect subjunctive are obsolete in spoken French and rare in written French.

Find the Beehive Cluster

Find the Beehive Cluster Cancer: Home of the Beehive Cluster Stargazing is part observation and part planning. No matter what time of year it is, you always have something cool to look at or you are planning out your future observations. Amateurs are always plotting their next conquest of a difficult-to-spot nebula or the first view of an old favorite star cluster. Take the Beehive Cluster, for example. Its in the constellation  Cancer, the Crab, which is a zodiac constellation that lies along  the  ecliptic, which is  the apparent path of the  Sun  across the sky throughout the year.  This means that Cancer is  visible for most observers in both the northern and southern hemispheres in the evening sky from late winter from about January through May. Then it disappears in the glare of the Sun for a few months before showing up in the early morning sky beginning in September.   Beehive Specs The Beehive is a little star cluster with the formal Latin name Praesepe, which means the manger. Its just barely a naked-eye object, and looks like a fluffy little cloud. You need a really good dark-sky site and reasonably low humidity to see it without using binoculars. Any good pair of 7Ãâ€"50 or 10Ãâ€"50 binoculars will work, and will show you a dozen or two stars in the cluster. When you look at the Beehive, you see stars that are about 600 light-years away from us.   There are about a thousand stars in the Beehive, some similar to the Sun. Many are red giants and white dwarfs, which are older than the rest of the stars in the cluster. The cluster itself is about 600 million years old. One of the interesting things about the Beehive is that it has very few massive, hot, bright stars. We know that the brightest, hottest and most massive stars usually last anywhere from ten to several hundred million years before they explode as supernovae. Since the stars we DO see in the cluster are older than this, either it lost all its massive members already, or perhaps it didnt start with many (or any). Open Clusters Open clusters are found throughout our galaxy. They usually contain up to a few thousand stars that were all born in the same cloud of gas and dust, which makes most of the stars in a given cluster roughly the same age. The stars in an open cluster are mutually gravitationally attracted to  other when they first form, but as they travel through the galaxy, that attraction can be  disrupted by passing stars and clusters. Eventually, an open clusters stars move so far apart that it  disintegrates and its stars are scattered to the galaxy. There are several known moving associations of stars that used to be open clusters. These stars are moving at roughly the same velocity but are not gravitationally bound in any way. Eventually they, too, will wander on their own paths through  the galaxy. The best examples of other open clusters are the Pleiades and the Hyades, in the constellation Taurus.

Creativity in Enterprise Essay Example | Topics and Well Written Essays - 1500 words

Creativity in Enterprise - Essay Example This essay discusses that  a business environment with students who have polished ideas in how they can put their ideas into real practice to improve the business enterprise and its performance is the purpose of module guidelines in an enterprise. A module has been meant to help students solve their business problems in an ample business environment by coming up with effective solutions. The knowledge gained from the module helps them to form part of good leadership in any business enterprise; by application of their creative tools and skills, they gain. The module knowledge enables the students understand how teamwork can promote the performance of the business.  From this study it is clear that  teamwork is a key issue to determine the success of a business, and it helps any business enterprise advance in its productivity and has promising returns. Therefore, it is important for students to understand that teamwork will help them in their performance of the business operation s as either managers or just mere employees. Every other employee in a business enterprise needs the other to promote the success of the business.  A workshop advances good relations between the managerial, entrepreneurial position leaders in the enterprise and the mere entrepreneurs. Use of workshops is a method in which entrepreneurs in a business collectively sit down and come up with fresh implementations into the business enterprise to advance its success.

Human resource Essay Example | Topics and Well Written Essays - 4500 words - 1

Human resource - Essay Example After exploring the salary structure and job performance evaluation, the best ways to increase employees’ salary in accordance to the company’s profit earnings will be explained. Upon exploring the significance of behavioural competencies with the skill development of each employee, decision of organizational study and hr development strategy particularly with the importance of trainings as well as learning and development through an open distance learning will be tackled followed by discussing the importance and impact of employee recognition in the context of employee relation. With regards to trade union issues, the differences between multi-union, single table, single union and partnership will be discussed followed by explaining the benefits and advantages of conducting a collective consultation like redundancy, transform of under takings, health safety, pension, and work place agreement. According to Roy Ballentine of Ballentine Finn & Co.; â€Å"Getting the right people in the right jobs is important because we are running a business that depends on human capital† (Alexander, 2009). It simply means that employing a person with sufficient skills and knowledge to perform a task could enable the organization meet the business objectives. A common problem that most HR managers are experiencing today is that hiring new employees who are capable of performing the job does not literally mean that the newly employed individuals would stay with the company for a long period of time. One of the most common reasons why newly hired employees would decide to leave the company is due to the fact that they could not fit in the organizational culture or the existing team within the department. For this reason, it is a challenge for HR managers to get the right people in position. Organizational culture is a paradigm developed by individuals within the organization which over time forms a strong pattern of behaviour and belief that could significantly affect

IMPORTING AND EXPORTING Essay Example for Free

IMPORTING AND EXPORTING Essay I think that this argument is in the best interests of the country as a whole because they would not be worried about jobs and it will keep the overall populations wages low to increase countrys overall manufacturing exports. Yes, China is a mercantilist Nation because Chinas commercial engagement with the rest of the world is largely contributed from mercantile theory. No mercantilism is not a bankrupt theory and it has a place in the modern world because to lower the cost of production and hence cheaper products to increase exports and domestic demand of such domestic goods. Yes China has an economic policy that can be characterized as neo-mercantilist. What should the United States, and other countries, do about this Chinas commercial engagement with the rest of the world is largely scripted from mercantile theory: export boosting policies that are meant to stimulate a balance of payment in Chinas favor, ie, manipulating their currency to keep it artificially devalued in support of cheap capital exports and a mechanism of forced high savings, which in effect promotes policies that subsidizes Chinese manufacturers (to lower their cost of production and hence cheaper products to increase exports and domestic demand of such domestic goods) at the expense of their own households and manufacturing jobs in the consumption-crazed US-and-Eurozone a process that leaves Chinas state-coffers endowed in huge surplus reserves. b) What incentive does China have to open its markets to foreign products? Why might China resist such a move? Incentives: By opening its markets to foreign products, China can exploit its comparative advantage and specialize in the production of goods that it produces most efficiently and to buy good that it produces less efficiently from other countries, even if this means buying goods from other countries that it could produce more efficiently itself. Hence, companies in China can lower their overall cost structure or improve the quality and functionality of their product offering, allowing them to compete more effectively. Besides, globalization is becoming

Essay example --

In the novel One Flew over the Cuckoo’s Nest by Ken Kesey we are introduced to the theme of the machine controlling the patients in the ward. The combine, as it is referred to several times throughout the novel, is a machine that is used in farming that is used for cutting crops. In Cuckoo’s Nest, the combine is used as a metaphor for society and how it controls, destroys and manipulates the patients. The character Nurse Ratched is a â€Å"high ranking official† (p. 165) of the combine with nearly every character in the novel under her control. With extreme intelligence, she uses her power to influence how the population of the ward acts and what they do. Fear is a major component of the nurse’s tactics as she uses it to get what she wants and gets things done exactly how she wants it. The two types of patients in the novel, the Acutes who are â€Å"still sick enough to be fixed† (p. 13) and the Chronics who â€Å"can’t be repaired† (p. 14) are treated much differently by the nurse and her staff as she must be more strict with the chronics and is allowed to be more lenient with the acutes. The ...

Benvenuto Cellini: The Man Who Made Art More Interesting

It seems that all of us are convinced by easy things, like how often people tell us that we can't have it all. It is always easier to believe that it is acceptable not to be able to draw because at least, we can sing. It is fine to not possess the skill for theater acting as long as we can dance. It is always easier not to have it all. Such idea can be counterattacked by not exactly mastering two art forms at a time. Disproving such claim is not achieved by trying to dance while singing even when singing just does not show in the blood and in the heart.To disprove such idea is simple: review history, especially the people who made it interesting. No one may ever be convinced with such argument – not until they meet a hooligan, a soldier, an author, a goldsmith, a sculptor, a musician and a painter rolled into one by the name of Benvenuto Cellini. Before introducing Benvenuto Cellini, it is best to pay tribute to his parents by recognizing them first. An artificer of musical in struments named Giovanni Cellini married a woman named Maria Granacci and settled in the Val d’Ambra.This couple had stayed together for a very long time, although it was only 18 years after their marriage when they were gifted with a child. Giovanni and Maria welcomed their third child Benvenuto in the family by giving him a name that, when translated in English, means â€Å"welcome. † As their child Benvenuto grew, the life of the Cellini family became more ideal for all of its members (Insecula, 2007). Born in Florence, Italy in November 1, 1500, Benvenuto’s family was also popular for being landowners in the Val d'Ambra.Three generations of Benvenuto’s family had settled in the Val d’Ambra. He was known for many different things. He was recognized for being a musician, soldier, painter and goldsmith (among his many other talents and skills) in the Renaissance Period (Insecula, 2007). Before Benvenuto was known as a sculptor, a musician or a wri ter, he was first inclined with his first love: metal works. Benvenuto was reluctant about being a musician because his heart feels for the arts of metal working even when his father, who had a strong inclination to music, wanted him to be a musician.Aside from being an artificer of musical instruments, music was also his father's talent. He wanted Benvenuto to develop this skill and kept his son away from metal works and design. Then again, Benvenuto stood up to follow his dreams and passion. His passion for metal work has indeed brought him to places and to more pedestals which his father, Giovanni, never expected (Insecula, 2007). Youthful likings got the better of Benvenuto. At fifteen, he grew up to be too ablazed by silver plates, vases and other decorative and significant elements produced from metal works.Giovanni, on the other hand, gave in because of the way Benvenuto had displayed his fondness for metal works. A goldsmith named Antonio di Sandro, who was more popularly kn own as Marcone, was where Giovanni sent his son for apprenticeship (NNDB, 2007). Benvenuto had definitely been successful with his craft. The place where he was native to recognized his skills as s goldsmith. However, Benvenuto was sent to Siena for six months for being involved in a fight with one of his colleagues. In Siena, he worked as a goldsmith for Fracastoro, also known as Francesco Castoro.As a goldsmith, he was also learning to play music at the same time. While mastering the art of playing the flute, Benvenuto moved to Bologna to be more successful in the goldsmith’s art. In Bologna, he was also recognized as a musician, specifically a flute player (NNDB, 2007). Benvenuto had been to many places. He had visited Pisa and resettled in Florence twice. At the early age of 19, he moved to Rome. He first tried and tested his skills on a silver casket. It was indeed successful and the people liked the way he worked.Because of this, he also produced silver candlesticks and made something for a living. Before Benvenuto knew it, he was also recognized by Pope Clement VII and made a vase for him. Today, one of his works can be seen in Vienna Museum called the â€Å"Leda and the Swan† where the said art was carried over for the Gonfaloniere Gabbriello Cesarino. The Leda of the Swan was famous for its being an artwork in a hard stone taking the wondrous image of Leda's torso and head (Gable, 2004). Undeniably, Benvenuto has established a name as a goldsmith not only in Italy but in history as well.On the other hand, Benvenuto, no matter how reluctant he was towards concentrating on a musical career, tried everything in his power to avoid making his father Giovanni feel bad and all the more frustrated. Since Benvenuto's father, Giovanni Cellini, was a musician, too, it can not be denied where Benvenuto got his skills in music from. Aside from being a goldsmith, Benvenuto had been known for being a musician even if it was not exactly his dream. Music , being his father's first passion, was also the art form his father encouraged him to study about all the time.The years where Giovanni had been trying to keep Benvenuto away from his family were also the same years when he tried to convince Benvenuto to concentrate music. He wanted Benvenuto to be known as a musician (The Harvard Classics, 2005). While Benvenuto loved metal crafts and art works, it never meant that he didn't have a space for music in his heart. Benvenuto did not deepen and worsen that frustratration of his father by focusing only on metal work and ignoring music and all its charms.However, Benvenuto was not as interested in music as he was in metal work and paintings. He was a man who knew how to play the flute and cornet but never fully concentrated on these skills. Benvenuto says that he would only play flute or cornet everytime his father was around, or simply because he wanted to please his father. Sometimes, he would play music and pretend to like what he was doing just so he would see his father happy. His father, on the other hand, would always cry in tears of joy everytime he hears the music Benvenuto played (Symonds, 2003).The reason why Benvenuto chose not to aggravate his father's frustration when it comes to music was because he was already frustrated with the other son. Benvenuto's brother, Cecchino, became a man destined to the profession of arms when Giovanni, their father, wanted him to become a jurist. Benvenuto was the son who pursued his own dreams and his father's, too, even when they were two different careers, two different talents, two totally different things. As a goldsmith, Benvenuto concentrated and learned two art forms at a time. When he was 15, he started learning about music, too.When he moved to places like Siena and Bologna, he spends his days as a goldsmith by playing flute at the same. In the said places, Benvenuto was recognized as a local flute-player. However, his inclinations towards music compared to h is inclination towards metal works are extremely different when it comes to the level of interest. Benvenuto had been taught by teachers, or what he regarded as â€Å"masters† about the basic things in metal works. He went through rigorous training and workshops to learn even the most complex and delicate side of the said craft.Benvenuto was recognized as a musician even when he did not undergo the trainings and workshops he had been through as a goldsmith. By watching people play, self-teaching and of course by accepting what such trait which he got from his father Giovanni, Benvenuto was able to succeed in this form of art, too (Insecula, 2007). He practiced playing the flute everyday and never skipped a day without practicing it even without the constant insistence of his father towards his learning of the said skill.It was not too long a wait when Benvenuto was recognized by the pope again. Benvenuto became one of the court-musicians of the pope (Panse, 2004). While some of uses are deeply convinced that still, we can't have most of it all, such idea was not something that Benvenuto bought. To Benvenuto, metal works was passion, music was a favor and sculpture was progress. His skills as a goldsmith later on developed to his interest in statues. Benvenuto did not grow up to have two careers. His talent as a goldsmith had later on evolved into a more serious craft: sculpture.As a sculptor, Benvenuto was able to come up with Mars, Vulcan and Jupiter silver statues which were famous for their large sizes. Jupiter can now be seen at the Detroit Institute of Arts (AARF, 2007). Benvenuto became more serious with this new craft and he paid great attention to this in the next years. He was able to come up with new statues in the 1540s. His great statues include Perseus with the head of Medua which he sculpted in 1545 to 1553 and The Nymph of Fontainebleau in 1542. Benvenuto had been very successful in his career as a sculptor that his works are displayed al l over the world.Some of the many world-renowned museums, institutions and art galleries that keep Benvenuto's statues are the following: State Museums of Florence and Palazzo Ruspoli both in Italy, Frick Collection and Metropolitan Museum of Art both in New York, Drawings from the Biblioteca Ambrosiana, Courtlauld Institute of Art in London, United Kingdom, National gallery of Austrialia in Canberra, Buenvenuto Cellini at the National Gallery Art in Washington D. C. , Benvenuto Cellini at the Louvre Musem in Paris, Kunsthistorisches Museum in Vienna and J. Paul Getty Museum in Los Angeles, California (Malyon, 2007)All these, Benvenuto definitely owes to a number of people. All his skills and talents and all the things he was recognized for – he owes it to his influences. Without his influences, he may not have known that such talents existed. He needed other people to help him realize his dreams. He needed his father's challenge to realize that he would rather be a goldsmith than a musician. He needed his teachers to train him and make him better with his talents and skills. He needed other great artists, too, and even the simple and most local ones, to give him an idea about other styles and techniques.

The NYU scholarship on public health graduate program

I am pleased to apply for the NYU scholarship on public health graduate program. Since learning is a continuous lifetime process, I always wanted to gain knowledge of something innovative that will make me a better, rational and worthy person.To complement with the dynamic changes of society and provide the high-end demands of daily life, every individual who thirsts for knowledge of information needs further studies in order to sustain such changes and demands. I deem that I will learn about the world’s philosophies and applications in adaptation of its very nature and its elements in connection to International Business and Management geared towards health care.My career objectives in taking up advance study in this field are to become a competent and knowledgeable person when it comes to governance and to learn more for the purpose of service. With the learning experiences that I will acquire in the University, I will be able to materialize all my intentions in serving othe r people especially those who are in need.I believe that my training and experiences have prepared me for this kind of task since I consider myself result-oriented with a strong entrepreneurship background. My passion for healthcare management has led me towards the publication of a self-motivational weight-loss book called, â€Å"Kimchi Diet.†Together with these skills, I have further honed my knowledge in the area of driving business process, qualitative and quantitative market research and customer service improvements. As a Hospital Strategic Planner, I have achieved significant results related to promoting the growth of the group to where I belong, developing innovative curriculum for effective new staff training thereby increasing overall client volume.In the same vein, I have incorporated my skills in designing and implementing E-commerce sites and web portals in HR communication when I worked at The Gillette Company in Boston Massachusetts. While there, I developed Co ntent Management System for various web projects within the company.I am positive that the innate leadership and powerful drive for service within me will be developed while I am in the institution. I bequeath my humblest leadership, dedication and school spirit for the quest of knowledge. With the acquired knowledge I will have, I am certain to elevate and make better changes in human life not only in the campus but in the community where I belong and intend to serve. My optimism will help bring understanding and wisdom to the all people who need my assistance and service.I want to extend my help to other students in integrating their interests in global, regional and current issues. Through my own dealings of life over the years and a handful of experiences in and out of the four-corners of the classroom, I have grown to be a more responsible and mature person.Indeed, acquiring training in Public Heath Graduate Program will be the first step that I need to take to be able to accom plish my goals. I believe this program will help eager and zealous students like me with its curriculum possessing local and international focus and commitment for excellence. The program is what I need to develop a fuller understanding about the dynamic nature of public health.

How to Parlay Your Consumer Magazine Experience into Trade Magazine Success

How to Parlay Your Consumer Magazine Experience into Trade Magazine Success I often find, at parties and at networking events, that even fellow journalists are rarely intrigued The truth, however, is that some of the best work I’ve done is for trade publications. Some of the coolest reporting stories I have to share have been made possible because these publications had the funds to send me to strange places to cover even stranger topics. The topics and the trade publications may not seem sexy, but the fatter paycheck, the friendly editors, and the challenge of discovering new and exciting fields certainly make them worth the effort of querying. If you haven’t had much luck with trade magazines so far, here are five quick ways you can parlay your consumer magazine or newspaper experience for the trades: 1. Take a consumer magazine or newspaper article you’ve written and identify the major trades in that story. For instance, I once wrote a piece for a national women’s magazine about women-only trains in India. I didn’t ever think it could be a trade story, so I was really surprised when an editor at â€Å"Trains† magazine paid me to reprint the story. If you look closely, you’ll find at least one major identifiable trade in every story that you write. Find a magazine that caters to that trade. Pitch it. 2. Most trade magazines are not dull, dry, and dreary, like the writing gurus would have you believe. Many of them feature articles that are written with just as much craft and care as those in consumer publications. I have won an award for a story I wrote for a trade that resonated with the judges because of its human aspect. Look through national and regional magazines and find ideas that could potentially work for trade magazines.   I often find new and breaking stories in the New York Times or the Wall Street Journal that other freelancers haven’t thought to pitch to trade magazine editors. 3. Tie your ideas to current events. When the Commonwealth Games came to Delhi in 2010, most freelancers I knew were (unsuccessfully) pitching to major newspapers and magazines. I, instead offered stories to a construction magazine and an engineering news magazine and earned several thousand dollars and a cover story. 4. When you travel, don’t forget to target these magazines. The trades have several US-based writers they can hire regularly but their networks are limited abroad. If you’re traveling out of the country, e-mail some of the trade magazine editors (even if you don’t know them) and offer to bring back something. The best-case scenario is that editors might just hand you assignments of their own even before you’ve left and the worst case is that you may come back with some fascinating ideas and an already established relationship with an editor. 5. Everything is a trade. Think about the truth of that statement for a minute. No matter what you’re writing about, you can find a trade magazine angle to it. And once you start noticing that potential, you’ll never run out of markets for your work.

Cationic Antimicrobial Peptides in Humans

Cationic Antimicrobial Peptides in Humans Antimicrobial peptides Introduction Cationic antimicrobial peptides (AMPs) are gene-encoded peptides of the host defence system made up of 12-50 amino acids, with at least 2 positive charges conferred by lysine and arginine residues and about 50% hydrophobic amino acids (Hancock and Scott 2000). They are produced from gene transcription and ribosomal translation and often, further proteolytically processed (Zhoa 2003). The peptides are folded so that non-polar amino acid side-chains form a hydrophobic face and polar, positively charged residues form a hydrophilic face (Robert and Hancock 1997). Expression of antimicrobial peptides can be constitutive or inducible by infectious or inflammatory stimuli like cytokines, bacteria and lipopolysaccharides (LPS) (Cunliffe and Mahida 2004). They have diverse structures to effectively kill a wide range of microbes at prone sites e. g the skin and lungs, and in secretions such as sweat and saliva (Yeaman and Yount 2004; Santamaria 2005). Many mammalian antimicrobial peptides rouse the host’s innate immune system (Jenssen et al 2006) instead of directly killing the host. Peptides which are found in living organisms from bacteria to plants, insects, fish, amphibians to mammals including humans (Kamysz 2005) are recorded in numerous existing databases e. g. AMSDb (Eukaryotic peptides) (Tossi and Sandri 2002), BAPDb (bacterial peptides), ANTIMIC (natural antimicrobial peptides) (Brahmachary et al 2004) and APPDb. Currently, 1831 peptides are hosted by the Antimicrobial peptide database with 99 antiviral, 453 antifungal, 100 anticancer and 1179 antibacterial peptides (The Antimicrobial Peptide database 2010). In humans, antimicrobial peptides are produced by granulocytes, macrophages and most epithelial and endothelial cells. They boost the immune system, have anti-neoplastic properties and help in regulating cell signalling and multiplication. Amphibian AMPs have been discovered from the skin of frogs from families ra nging from Iomedusa, Pipidae, Hyperoliidae, Ranidae, Hylidae, Discoglossidae, Agalychnis and Litoria. The structure of these peptides as unravelled by CD spectroscopy, NMR spectroscopy and molecular modeling (Suh et al 1996) have been found to be generally 10-46 amino acid residues long (Rollins-Smith et al 2005), mostly linear and simple-structured, (Conlon et al 2004) the majority being hydrophobic, cationic and possessing an amphipathic a-helix in nature. Following production, they are stored in the granular glands (poison glands) of skin dermal layer to be secreted in response to injury (Bovbjerg 1963), or as defence against pathogenic bacteria, fungi, viruses and parasites. Biologically active molecules including antimicrobial peptides are produced as large proteins harbouring a signal and an acidic propiece which get cut off to give an active peptide prior to or at secretion from the poison glands (Amiche et al 1999). Cationic peptides are also expressed in the gastric mucosa cells and in the intestinal tract (Kamysz 2005). The best-known peptides isolated from frogs are caeruleins, tachykinins, bradykinins, thyrotropin- releasing hormone (Barra and Simmaco 1995), brevinins, esculentins, magainins, ranatuerins and temporins (Conlon et al 2004). In the past, peptides were extracted using solvents like methanol or acid from the skins of amphibians after sun-drying but with concomitant dwindling of many frog species, other alternative techniques have emerged, one of which comprises stimulating the frog using mild electricity and collecting the skin secretion; 2-4 weeks after, the secretion can be re-collected after replenishment of the glands (Barra and Simmaco 1995). Large amounts of small peptides and their analogues which are resistant to protease cleavage and contain D-amino acids can be chemically synthesised while larger peptides can be expressed in a prokaryotic host from cloned cDNAs coding for a fusion protein (Piers et al 1993). An efficient means of producing therapeutic peptides in transgenic mice red blood cells has been explained by Sharma et al (1994) whereby the required peptide is collected from proteolytic cleavage from the fusion protein where the peptide is at the C-terminal end of human a-globin.

Toyota recall is not safe Essay Example | Topics and Well Written Essays - 1250 words

Toyota recall is not safe - Essay Example One of these companies is Toyota Motor Corporation, commonly known as Toyota. This is a multinational corporation with its headquarters in Japan. Toyota has factories in most parts of the world which makes it one of the world’s largest automaker (Toyota, 2010). The cars manufactured by Toyota were considered the best until the series of accidents that were caused by the cars’ design. Some say that the issue was not very serious and it was unnecessarily amplified by its competitors over the media. Very recently, several vehicles faced the problem of the accelerator pedal getting stuck which caused unintended acceleration and hence many accidents. As a corrective measure, Toyota has decided to recall its sold cars and fix them (Reed, P., 2010). According to a source, by January 28, 2010, Toyota had announced recalls of about 5.2 million cars for the pedal entrapment/floor mat problem, and an additional 2.3 million cars for the accelerator pedal problem. Out of these, almost 1.7 million cars have both these problems (Toyota Press Release, 2010). In addition to this, it cut down on its production to a great extent as well. Other companies that have faced the same problems include Honda, Ford, etc. However, the problem faced by these org anizations did not affect their image and financial condition at the same scale as Toyota. Now when we talk about this incident and Toyota’s reaction of recalling the cars that were potentially damaged, people often take two different sides. Some say that the Toyota recall was a good idea while some disagree. It is very important that all aspects of this issue are discussed so that we can understand the strategy better from all angles. Therefore, in this paper, we will discuss both sides of the argument in the coming paragraphs, firstly discussing the arguments for the Toyota recall. The Toyota recall is believed to be the best thing for everyone. We noted in the